Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers.
It can be predicted from the concentration-time data of a single-dose administration.Study Flashcards On Kinetics: Lecture 8: Multiple Dose Regimens at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the.Multiple-variable dose regimen for treating TNFalpha-related disorders Download PDF Info Publication number US20060009385A1.Missed doses greater than 5 half-lives later should be omitted because of their minimal impact.Translate Multiple dose regimens to English online and download now our free translation software to use.Enhanced efficacy of single-dose versus multi-dose azithromycin. dose regimen would be at least as effective as the same dose. dose pharmacokinetic data were.
Intermittent short IV infusions prevent transient extreme high plasma levels of a drug and so are better tolerated even though steady-state may not be attained.
Just before admin. of the 2nd dose, thereafter, doses should be taken regularly after the administration of each dose.Translate Multiple dose regimens to English online and download now our free translation software to use at.
Idealized insulin effect provided by a multiple-dose regimen consisting of injections (arrows) of short-acting insulin (Reg).Evaluation of a multiple-dose regimen of oral sumatriptan for the acute treatment of migraine.No other treatment-related side effects occurred in patients on the multiple-dose regimens of ZITHROMAX with. rats, and dogs given multiple doses of azithromycin.The pharmacokinetic aspects of treatment schedules which involve more than one dose of a drug are discussed below.It depends on the dosing interval and the elimination rate constant.
The kinetics of later doses are only superimposed on earlier ones.
It is not a DIRECT indication of the systemic conc. of the drug.Equal doses of test and a reference product may each be administered repeatedly in turn (two-way cross-over) to steady state, separated by a time period required to completely eliminate the drug from the body.T1 - Single- vs multiple-dose pharmacokinetics of clozapine in psychiatric patients.
For each time point, then, the predicted plasma concentration is the sum of the residual concentration resulting from each previous dose. (This holds true even if the dosing interval is not fixed).
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.They can reveal changes that would not be obvious in a single dose study.